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EP 1 159 287 A1

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(43) Date of publication: 05.12.2001 Bulletin 2001/49 (21) Application number: 00917795.7 (22) Date of filing: 09.03.2000

(51) International Patent Classification (IPC)7: C07H 21/04, C07K 14/00, C07K 16/00, C12N 15/00, C12N 15/63, C12N 15/85, C12N 15/86, C12Q 1/68, G01N 33/53 (86) International application number: PCT/US0006/049 (87) International publication number: WO 0055/175 (21.09.2000 Gazette 2000/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.03.1999 US 124144 P 11.06.1999 US 138574 P 03.12.1999 US 168667 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Laytonsville, MD 20882 (US) KOMATSOULIS, George Silver Spring, MD 20901 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)