(19)

(11)

EP 1 159 354 A1

(12)

(43) Date of publication: 05.12.2001 Bulletin 2001/49 (21) Application number: 99912606.3 (22) Date of filing: 17.03.1999

(51) International Patent Classification (IPC)7: C09B 67/00, D21C 9/10, D21H 21/32, D06L 3/00, D06P 5/00, A61K 7/135, A01N 55/02, A61L 15/20, C02F 1/00, C02F 1/50, A61K 31/40, C07B 33/00, G02B 5/22 (86) International application number: PCT/US9905/795 (87) International publication number: WO 0052/101 (08.09.2000 Gazette 2000/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.03.1999 US 123005 P (71) Applicant: Case Western Reserve University Cleveland, OH 45011 (US)

(72) Inventors: ORTIZ, Rafael Milford, OH 45150 (US) KITKO, David, Johnathan Cincinnati, OH 45241 (US) BURNS, Michael, Eugene Hamilton, OH 45011 (US) HEINZMAN, Stephen, Wayne Whitely Bay NE26 4QW (GB) WILLEY, Alan, David Cincinnati, OH 45202 (US) JEFFREYS, Brian B-1850 Grimbergen (BE) BURCKETT-ST. LAURENT, James C.T.R. Cincinnati, OH 45249 (US) VINSON, Phillip, Kyle Fairfield, OH 45014 (US) TRAJANO, Trace, Wendell, de Guzman Sampaloc,Manila, 1008 (PH) (74) Representative: Kador & Partner  Corneliusstrasse 15 80469 München 80469 München (DE)