(19)

(11)

EP 1 159 414 A1

(12)

(43) Date of publication: 05.12.2001 Bulletin 2001/49 (21) Application number: 00964909.6 (22) Date of filing: 25.09.2000

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 15/82, C12N 15/85, C12N 15/70 (86) International application number: PCT/US0021/982 (87) International publication number: WO 0123/537 (05.04.2001 Gazette 2001/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.09.1999 US 155640 P (71) Applicants: Cyto Pulse Sciences, Inc. Hanover, MD 21076 (US) THE UNIVERSITY OF MARYLAND AT BALTIMORE BaltimoreMaryland 21201-1627 (US) King, Alan D. Takoma Park, MD 20912 (US) Malone, Robert W. Pasadena, MD 21122 (US)	(72) Inventors: KING, Alan, D. Takoma Park, MD 20912 (US) MALONE, Robert, W. Pasadena, MD 21122 (US) (74) Representative: Newby, Martin John  JY & GW Johnson,Kingsbourne House,229-231 High Holborn London WC1V 7DP London WC1V 7DP (GB)