(19)
(11) EP 1 159 419 A1

(12)

(43) Date of publication:
05.12.2001 Bulletin 2001/49

(21) Application number: 00912015.5

(22) Date of filing: 24.02.2000
(51) International Patent Classification (IPC)7C12N 15/12, C07K 14/47, A61K 38/17, G01N 33/53, C12Q 1/68, C12N 15/62, C07K 16/18
(86) International application number:
PCT/US0005/004
(87) International publication number:
WO 0053/757 (14.09.2000 Gazette 2000/37)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 08.03.1999 WO PCT/US99/05028
12.03.1999 US 123957 P
02.06.1999 WO PCT/US99/12252
20.07.1999 US 144758 P
26.07.1999 US 145698 P
01.09.1999 WO PCT/US99/20111
15.09.1999 WO PCT/US99/21090
30.11.1999 WO PCT/US99/28313
30.11.1999 WO PCT/US99/28409
02.12.1999 WO PCT/US99/28565
05.01.2000 WO PCT/US00/00219
18.02.2000 WO PCT/US00/04341
18.02.2000 WO PCT/US00/04342
22.02.2000 WO PCT/US00/04414

(71) Applicant: Genentech, Inc.
South San Francisco, CA 94080-4990 (US)

(72) Inventors:
  • ASHKENAZI, Avi, J.
    San Mateo, CA 94402 (US)
  • BAKER, Kevin, P.
    Darnestown, MD 20878 (US)
  • FERRARA, Napoleone
    San Francisco, CA 94109 (US)
  • GERBER, Hanspeter
    San Francisco, CA 94107 (US)
  • GERRITSEN, Mary, E.
    San Mateo, CA 94402 (US)
  • GODDARD, Audrey
    San Francisco, CA 94131 (US)
  • GURNEY, Austin, L.
    Belmont, CA 94002 (US)
  • HILLAN, Kenneth, J.
    San Francisco, CA 94114 (US)
  • MARSTERS, Scot, A.
    San Carlos, CA 94070 (US)
  • PAONI, Nicholas, F.
    Belmont, CA 94002 (US)
  • PITTI, Robert, M.
    El Cerrito, CA 94530 (US)
  • WATANABE, Colin, K.
    Moraga, CA 94556 (US)
  • WILLIAMS, P., Mickey
    Half Moon Bay, CA 94019 (US)
  • WOOD, William, I.
    Hillsborough, CA 94010 (US)

(74) Representative: Denison, Christopher Marcus et al
Mewburn EllisYork House23 Kingsway
London WC2B 6HP
London WC2B 6HP (GB)

   


(54) PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION