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(11)

EP 1 159 422 A1

(12)

(43) Date of publication: 05.12.2001 Bulletin 2001/49 (21) Application number: 99965090.6 (22) Date of filing: 02.12.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, A61K 39/395, C07K 16/18, C12N 15/13, C12N 15/11, G01N 33/53, C12Q 1/68, C12N 15/62 (86) International application number: PCT/US9928/551 (87) International publication number: WO 0053/750 (14.09.2000 Gazette 2000/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.03.1999 WO PCT/US99/05028 01.09.1999 WO PCT/US99/20111 29.10.1999 US 162506 P 30.11.1999 WO PCT/US99/28313 01.12.1999 WO PCT/US99/28634 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)

(72) Inventors: BOTSTEIN, David Belmont, CA 94002 (US) GODDARD, Audrey San Francisco, CA 94131 (US) GURNEY, Austin, L. Belmont, CA 94002 (US) ROY, Margaret, Ann San Francisco, CA 94123 (US) WATANABE, Colin, K. Moraga, CA 94556 (US) WOOD, William, I. Hillsborough, CA 94010 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)