(19)

(11)

EP 1 161 201 A2

(12)

(88) Date of publication A3: 14.12.2000 (43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00915782.7 (22) Date of filing: 16.02.2000

(51) International Patent Classification (IPC)7: A61F 2/00, A61F 13/00, A61K 9/14, A61K 35/12, A61K 38/00 (86) International application number: PCT/US0003/972 (87) International publication number: WO 0048/550 (24.08.2000 Gazette 2000/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.02.1999 US 250370 (71) Applicant: Sulzer Biologics, Inc. Wheatridge, CO 80033 (US)	(72) Inventors: ATKINSON, Brent Lakewood, CO 80215 (US) BENEDICT, James, J. Arvada, CO 80007 (US) (74) Representative: Harrison Goddard Foote  Belgrave HallBelgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)