(19)

(11)

EP 1 161 222 A1

(12)

(43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00917685.0 (22) Date of filing: 29.02.2000

(51) International Patent Classification (IPC)7: A61K 7/06 (86) International application number: PCT/US0005/300 (87) International publication number: WO 0051/558 (08.09.2000 Gazette 2000/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.03.1999 US 122925 P (71) Applicant: UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER Dallas, TX 75235-9094 (US)

(72) Inventors: FULMER, Andrew, Wayne West Chester, OH 45069 (US) TIESMAN, Jay, Patrick Fairfield, OH 45014 (US) DEGENHARDT, Charles, Raymond Cincinnati, OH 45240 (US) EICKHOFF, David, Joseph Edgewood, KY 41017 (US) MCIVER, John, McMillan Cincinnati, OH 45241 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)