(19)
(11) EP 1 161 236 A1

(12)

(43) Date of publication:
12.12.2001 Bulletin 2001/50

(21) Application number: 00907111.9

(22) Date of filing: 02.02.2000
(51) International Patent Classification (IPC)7: A61K 31/22, A61P 3/06, A61K 9/28
(86) International application number:
PCT/US0002/626
(87) International publication number:
WO 0053/173 (14.09.2000 Gazette 2000/37)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 08.03.1999 US 123227 P
09.03.1999 US 264744

(71) Applicant: Merck & Co., Inc.
Rahway,New Jersey 07065-0907 (US)

(72) Inventors:
  • TILLYER, Richard, D.
    Rahway, NJ 07065-0907 (US)
  • REIDER, Paul, J.
    Rahway, NJ 07065-0907 (US)
  • GRABOWSKI, Edward, J., J.
    Rahway, NJ 07065-0907 (US)
  • XU, Feng
    Rahway, NJ 07065-0907 (US)
  • VEGA, Jose, M.
    Rahway, NJ 07065-0907 (US)

(74) Representative: Thompson, John Dr. et al
Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) DIHYDROXY OPEN-ACID AND SALTS OF HMG-CO-A REDUCTASE INHIBITORS