(19)
(11) EP 1 161 258 A1

(12)

(43) Date of publication:
12.12.2001 Bulletin 2001/50

(21) Application number: 00925874.0

(22) Date of filing: 17.03.2000
(51) International Patent Classification (IPC)7A61K 38/48, A61K 38/57, A61K 38/17, A61K 38/39, A61P 35/00
(86) International application number:
PCT/US0007/154
(87) International publication number:
WO 0054/801 (21.09.2000 Gazette 2000/38)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 17.03.1999 US 270982

(71) Applicant: EntreMed, Inc.
Rockville, MD 20850 (US)

(72) Inventors:
  • PAPATHANASSIU, Adonia E.
    Silver Springs, MD 20910 (US)
  • GREEN, Shawn J.
    Vienna, VA 22182 (US)

(74) Representative: Stevens, Ian Edward 
Eric Potter Clarkson,Park View House,58 The Ropewalk
Nottingham NG1 5DD
Nottingham NG1 5DD (GB)

   


(54) COMPOSITIONS AND METHODS OF USE OF LDL-LIKE RECEPTOR LIGANDS FOR THE TREATMENT OF CANCER AND ANGIOGENIC-BASED DISEASE