(19)

(11)

EP 1 161 451 A2

(12)

(88) Date of publication A3: 30.11.2000 (43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00913602.9 (22) Date of filing: 25.02.2000

(51) International Patent Classification (IPC)7: C07K 14/52, C12N 5/10, C12N 5/16, C12N 15/19, C12N 15/63, A61K 38/19, A61K 38/16 (86) International application number: PCT/US0004/722 (87) International publication number: WO 0050/620 (31.08.2000 Gazette 2000/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.02.1999 US 122099 P 28.05.1999 US 136788 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20878 (US)	(72) Inventors: YU, Guo-Liang Berkeley, CA 94705 (US) NI, Jian Rockville, MD 20853 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)