(19)

(11)

EP 1 161 454 A2

(12)

(88) Date of publication A3: 11.01.2001 (43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00903839.9 (22) Date of filing: 15.02.2000

(51) International Patent Classification (IPC)7: C07K 14/78, C12N 15/12, C12N 15/63, C12N 1/38, C12N 5/06, A61K 38/39, A61P 35/00 (86) International application number: PCT/GB0000/520 (87) International publication number: WO 0047/622 (17.08.2000 Gazette 2000/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.02.1999 GB 9903408 (71) Applicant: Oxford Biomedica (UK) Limited Oxford 0X4 4GA (GB)	(72) Inventors: MAZARAKIS, Nicholas Chiswick,London W4 3EJ (GB) MARTIN-RENDON, Enca Sandford-on-Thames,Oxon OX4 4SD (GB) KINGSMAN, Susan Mary Appleton,Oxon OX13 5PP (GB) (74) Representative: Harding, Charles Thomas et al D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)