(19)

(11)

EP 1 161 525 A2

(12)

(88) Date of publication A3: 11.01.2001 (43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00913904.9 (22) Date of filing: 13.03.2000

(51) International Patent Classification (IPC)7: C12N 15/00, A01K 67/027, A61K 49/00, A61P 25/28, A61K 35/30 (86) International application number: PCT/US0006/526 (87) International publication number: WO 0053/738 (14.09.2000 Gazette 2000/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.03.1999 US 124301 P (71) Applicant: BROWN UNIVERSITY RESEARCH FOUNDATION Providence, RI 02912 (US)	(72) Inventors: ALBERINI, Cristina, M. Providence, RI 02912 (US) BEAR, Mark, F. Bristol, RI 02806 (US) COOPER, Leon, N. Providence, RI (US) TAUBENFELD, Stephen, M. Providence, RI 02096 (US) WIIG, Kjesten, A. Providence, RI 02906 (US) (74) Representative: Chapman, Paul Gilmour et al Cruikshank & Fairweather,19 Royal Exchange Square Glasgow G1 3AE Glasgow G1 3AE (GB)