(19)

(11)

EP 1 161 529 A2

(12)

(88) Date of publication A3: 18.01.2001 (43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00917887.2 (22) Date of filing: 09.03.2000

(51) International Patent Classification (IPC)7: C12N 15/10, C12N 15/55, C12N 9/14, C12Q 1/68 (86) International application number: PCT/US0006/497 (87) International publication number: WO 0053/744 (14.09.2000 Gazette 2000/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.03.1999 US 267118 26.03.1999 US 276860 14.06.1999 US 332835 (71) Applicant: Diversa Corporation San Diego, CA 92121 (US)	(72) Inventors: SHORT, Jay, M. Rancho Santa Fe, CA 92067 (US) FREY, Gerhard, Johann San Diego, CA 92129 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)