(19)

(11)

EP 1 161 533 A1

(12)

(43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00917794.0 (22) Date of filing: 08.03.2000

(51) International Patent Classification (IPC)7: C12N 15/12, A61K 35/12 (86) International application number: PCT/US0006/038 (87) International publication number: WO 0053/759 (14.09.2000 Gazette 2000/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.03.1999 US 123666 P (71) Applicant: Atlantic Biopharmaceuticals, Inc. Cambridge, MA 02138 (US)	(72) Inventors: LINDSAY, Stace Cambridge, MA 02140 (US) MULROY, Robert Cambridge, MA 02138 (US) SEMENIUK, Daniel Lawrenceville, GA 30043 (US) (74) Representative: Ackermann, Joachim, Dr.  Postfach 11 13 26 60048 Frankfurt am Main 60048 Frankfurt am Main (DE)