(19)

(11)

EP 1 161 542 A1

(12)

(43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00911091.7 (22) Date of filing: 20.03.2000

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 9/10, C12N 1/21, A01H 5/00, C07C 57/03, C07C 57/12, A61K 38/45, A61K 31/202, A23L 1/30 (86) International application number: PCT/GB0001/035 (87) International publication number: WO 0055/330 (21.09.2000 Gazette 2000/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.03.1999 GB 9906307 18.02.2000 GB 0003869 (71) Applicant: UNIVERSITY OF BRISTOL CliftonBristol BS8 1TH (GB)	(72) Inventor: NAPIER, J.A.IACR - Long Ashton Research Station Long Ashton,Bristol BS41 9AF (GB) (74) Representative: Hale, Stephen Geoffrey et al JY & GW Johnson,Kingsbourne House,229-231 High Holborn London WC1V 7DP London WC1V 7DP (GB)