(19)

(11)

EP 1 161 543 A1

(12)

(43) Date of publication: 12.12.2001 Bulletin 2001/50 (21) Application number: 00910595.8 (22) Date of filing: 17.01.2000

(51) International Patent Classification (IPC)7: C12N 15/57, C12N 9/64, C12N 15/63, C12N 5/10, C07K 16/40, G01N 33/573, C12Q 1/37 (86) International application number: PCT/EP0000/344 (87) International publication number: WO 0044/913 (03.08.2000 Gazette 2000/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.01.1999 GB 9901947 (71) Applicants: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB) SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: SOUTHAN, Christopher DonaldSmithKline Beecham Ph. HarlowEssex CM19 5AW (GB) PALMER, Leslie King of Prussia, PA 19406 (US) ZHU, Yuan King of Prussia, PA 19406 (US) LI, Xiaotong King of Prussia, PA 19406 (US) (74) Representative: Crump, Julian Richard John et al FJ Cleveland & Company,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)