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(11)

EP 1 162 880 A1

(12)

(43) Date of publication: 19.12.2001 Bulletin 2001/51 (21) Application number: 00919555.3 (22) Date of filing: 22.03.2000

(51) International Patent Classification (IPC)7: A01N 1/00, A61K 35/52, A61K 38/04, A61K 38/08, A61K 39/385, A61K 39/395, C07K 7/06, C07K 14/705, C07K 16/28, G01N 33/543, G01N 33/68 (86) International application number: PCT/US0007/686 (87) International publication number: WO 0056/144 (28.09.2000 Gazette 2000/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.03.1999 US 125504 P (71) Applicant: University of Virginia Charlottesville, VA 22903 (US)	(72) Inventors: HERR, John, C. Charlottesville, VA 22901 (US) NAABY-HANSEN, Soren London NW7 1DE (GB) FLICKINGER, Charles, J. Charlottesville, VA 22903 (US) SHETTY, Jagathpala Charlottesville, VA 22903 (US) (74) Representative: Lucas, Brian Ronald et al Lucas & Co. 135 Westhall Road Warlingham Surrey CR6 9HJ Warlingham Surrey CR6 9HJ (GB)