(19)

(11)

EP 1 162 961 A2

(12)

(88) Date of publication A3: 25.05.2000 (43) Date of publication: 19.12.2001 Bulletin 2001/51 (21) Application number: 99969022.5 (22) Date of filing: 10.09.1999

(51) International Patent Classification (IPC)7: A61K 31/00 (86) International application number: PCT/US9920/840 (87) International publication number: WO 0015/209 (23.03.2000 Gazette 2000/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.09.1998 US 99906 P (71) Applicants: The Scripps Research Institute La Jolla, CA 92037 (US) California Institute of Technology Pasadena, CA 91125 (US)	(72) Inventors: DERVAN, Peter San Marino, CA 91108 (US) GOTTESFELD, Joel, M. La Jolla, CA 92037 (US) LONG, John, J. Tonawanda, NY 14150 (US) (74) Representative: Roques, Sarah Elizabeth et al J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)