(19)

(11)

EP 1 162 966 A1

(12)

(43) Date of publication: 19.12.2001 Bulletin 2001/51 (21) Application number: 00921401.6 (22) Date of filing: 17.03.2000

(51) International Patent Classification (IPC)7: A61K 31/135 (86) International application number: PCT/US0007/202 (87) International publication number: WO 0056/317 (28.09.2000 Gazette 2000/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV RO SI (30) Priority: 19.03.1999 US 125149 P (71) Applicant: KNOLL PHARMACEUTICAL COMPANY Mount Olive, NJ 07828-1234 (US)	(72) Inventors: MENDEL, Carl, M.  (US) SEATON, Timothy, B.  (US) WEINSTEIN, Steve, P.  (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)