(19)

(11)

EP 1 163 013 A2

(12)

(88) Date of publication A3: 22.03.2001 (43) Date of publication: 19.12.2001 Bulletin 2001/51 (21) Application number: 00912305.0 (22) Date of filing: 24.03.2000

(51) International Patent Classification (IPC)7: A61K 51/12 (86) International application number: PCT/CA0000/326 (87) International publication number: WO 0057/924 (05.10.2000 Gazette 2000/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.03.1999 US 126379 P (71) Applicant: London Health Sciences Centre London, Ontario N6A 4G5 (CA)	(72) Inventors: ZABEL, Pamela Louise St. Mary's, Ontario N4X 1A6 (CA) DUNN, Kent Burlington, Ontario L7N 1N1 (CA) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)