(19)

(11)

EP 1 163 203 A1

(12)

(43) Date of publication: 19.12.2001 Bulletin 2001/51 (21) Application number: 00904644.2 (22) Date of filing: 02.02.2000

(51) International Patent Classification (IPC)7: C07C 69/30, C07C 67/28, A61K 31/22, A61P 3/06 (86) International application number: PCT/US0002/627 (87) International publication number: WO 0053/566 (14.09.2000 Gazette 2000/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.03.1999 US 123247 P 09.03.1999 US 264745 (71) Applicant: Merck & Co., Inc. Rahway, New Jersey 07065-0907 (US)	(72) Inventors: TILLYER, Richard, D. Rahway, NJ 07065-0907 (US) REIDER, Paul, J. Rahway, NJ 07065-0907 (US) GRABOWSKI, Edward, J., J. Rahway, NJ 07065-0907 (US) XU, Feng Rahway, NJ 07065-0907 (US) (74) Representative: Thompson, John Dr.  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)