(19)

(11)

EP 1 163 367 A2

(12)

(88) Date of publication A3: 21.12.2000 (43) Date of publication: 19.12.2001 Bulletin 2001/51 (21) Application number: 00907817.1 (22) Date of filing: 09.03.2000

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/GB0000/807 (87) International publication number: WO 0055/363 (21.09.2000 Gazette 2000/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.03.1999 GB 9905807 (71) Applicants: Amersham Pharmacia Biotech UK Ltd. Amersham, Bucks HP7 9LL (GB) Amersham Pharmacia Biotech Inc Piscataway, N.J. 08855-1327 (US)	(72) Inventors: THOMAS, Nicholas Cardiff CF4 8RU (GB) WAGGONER, Alan Pittsburg, PA 15213 (US) (74) Representative: Rollins, Anthony John et al Group Patents, Nycomed Amersham plc, White Lion Road Amersham, Buckinghamshire HP7 9LL Amersham, Buckinghamshire HP7 9LL (GB)