(19)

(11)

EP 1 163 371 A2

(12)

(88) Date of publication A3: 05.04.2001 (43) Date of publication: 19.12.2001 Bulletin 2001/51 (21) Application number: 00915885.8 (22) Date of filing: 25.02.2000

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US0004/939 (87) International publication number: WO 0050/644 (31.08.2000 Gazette 2000/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.02.1999 US 259467 (71) Applicant: Mosaic Technologies Waltham, MA 02451 (US)	(72) Inventors: ADAMS, Christopher, P. Somerville, MA 02144 (US) BOLES, T., Christian Waltham, MA 02451 (US) WEIR, Lawrence Hopkinton, MA 01748 (US) DHANDA, Rahul, K. Somerville, MA 02143 (US) SUMMERS, Nevin, M. Brookline, MA 02446 (US) (74) Representative: Holdcroft, James Gerald, Dr. et al Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)