(19)

(11)

EP 1 165 027 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00911409.1 (22) Date of filing: 28.03.2000

(51) International Patent Classification (IPC)7: A61K 7/13, A61K 7/06 (86) International application number: PCT/JP0001/895 (87) International publication number: WO 0059/459 (12.10.2000 Gazette 2000/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.03.1999 JP 8753699 (71) Applicant: Lion Corporation Tokyo 130-8644 (JP)	(72) Inventors: ONUKI, Takeshi Sumida-ku,Tokyo 130-8644 (JP) NOGUCHI, Mutsumi Sumida-ku,Tokyo 130-8644 (JP) MITAMURA, Joji Sumida-ku,Tokyo 130-8644 (JP) (74) Representative: Stuart, Ian Alexander et al MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)