(19)

(11)

EP 1 165 039 A2

(12)

(88) Date of publication A3: 11.01.2001 (43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00925137.2 (22) Date of filing: 24.03.2000

(51) International Patent Classification (IPC)7: A61K 7/48 (86) International application number: PCT/EP0002/629 (87) International publication number: WO 0057/840 (05.10.2000 Gazette 2000/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.03.1999 JP 8396199 (71) Applicant: Pentapharm A.G. CH-4052 Basel (CH)	(72) Inventor: NAKAYAMA, Hiroki,Pentapharm Japan Corporation Tokyo 160-0023 (JP) (74) Representative: Braun, André  BRAUN & PARTNER Patent-, Marken-, Rechtsanwälte Reussstrasse 22 4054 Basel 4054 Basel (CH)