(19)

(11)

EP 1 165 046 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00921506.2 (22) Date of filing: 29.03.2000

(51) International Patent Classification (IPC)7: A61K 9/107, A61K 47/18, A61K 31/05 (86) International application number: PCT/US0008/379 (87) International publication number: WO 0059/472 (12.10.2000 Gazette 2000/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.04.1999 US 128428 P 29.12.1999 US 474240 (71) Applicant: BAXTER INTERNATIONAL INC. Deerfield, Illinois 60015 (US)	(72) Inventors: PEJAVER, Satish, K. Bridgewater, NJ 08807 (US) MOTHERAM, Rajeshwar Wilmington, DE 19809 (US) (74) Representative: Dee, Ian Mark  Eric Potter Clarkson, Park View House, 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)