(19)

(11)

EP 1 165 098 A2

(12)

(88) Date of publication A3: 05.04.2001 (43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00912300.1 (22) Date of filing: 23.03.2000

(51) International Patent Classification (IPC)7: A61K 33/24, A61K 31/555, A61P 35/00 (86) International application number: PCT/CA0000/320 (87) International publication number: WO 0057/860 (05.10.2000 Gazette 2000/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.03.1999 US 126376 P (71) Applicant: Centre for Translational Research in Cancer Montreal, Québec H3T 1E2 (CA)	(72) Inventors: SANDOR, Victor, A. Montreal, Québec H3V 1H4 (CA) SCRIVENS, Paul, James Montreal, Québec H2K 4B2 (CA) (74) Representative: Jacob, Reuben Ellis  Edward Evans Barker Clifford's Inn, Fetter Lane London EC4A 1BZ London EC4A 1BZ (GB)