(19)
(11) EP 1 165 106 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
27.07.2005 Bulletin 2005/30

(45) Mention of the grant of the patent:
25.05.2005 Bulletin 2005/21

(21) Application number: 00912310.0

(22) Date of filing: 30.03.2000
(51) International Patent Classification (IPC)7: A61K 35/74, A61K 31/7088, A61P 35/00
(86) International application number:
PCT/CA2000/000342
(87) International publication number:
WO 2000/059518 (12.10.2000 Gazette 2000/41)

(54)

COMPOSITION AND METHOD FOR INDUCING APOPTOSIS IN PROSTATE CANCER CELLS BY M-DNA AND MCC

ZUSAMMENSETZUNG UND METHODE ZUR INDUZIERUNG VON APOPTOSIS IN PROSTATAKREBSZELLEN MITTELS M-DNA UND MCC

COMPOSITION ET PROCEDE PERMETTANT D'INDUIRE UNE APOPTOSE DANS DES CELLULES CANCEREUSES DE LA PROSTATE Ä L'AIDE DE M-DNA ET MCC

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 01.04.1999 US 127451 P

(43) Date of publication of application:
02.01.2002 Bulletin 2002/01

(73) Proprietor: Bioniche Life Sciences Inc.
Belleville, Ontario K8N 5J2 (CA)

(72) Inventors:
  • PHILLIPS, Nigel, C.
    Point-Claire, Quebec H9R 1J6 (CA)
  • FILION, Mario, C.
    Montreal, Quebec H2G 1K3 (CA)
  • READER, Stéphanie
    Ste-Julie, Quebec, J3E 1E3 (CA)

(74) Representative: Dey, Michael, Dr. et al
Weickmann & Weickmann, Patentanwälte, Postfach 86 08 20
81635 München
81635 München (DE)


(56) References cited: : 
WO-A-99/07383
   
  • MORALES A ET AL: "Immunotherapy of an experimental adenocarcinoma of the prostate" JOURNAL OF UROLOGY,US,BALTIMORE, MD, vol. 153, May 1995 (1995-05), pages 1706-1710, XP002100764 ISSN: 0022-5347
  • FILION M C ET AL: "Mycobacterium phlei cell wall complex, a new anti-tumoral agent, induces IL-12 synthesis by monocyte-macrophages via associated DNA" BLOOD,US,W.B. SAUNDERS, PHILADELPHIA, VA, vol. 90, no. 10, SUPPL. 01, 5 December 1997 (1997-12-05), page 58B XP002085542 ISSN: 0006-4971
  • FILION M C ET AL: "MYCOBACTERIAL CELL WALL - DNA COMPLEX INDUCES APOPTOSIS IN CANCER CELLS" JOURNAL OF PHARMACY AND PHARMACOLOGY,LONDON,GB, vol. 50, no. SUPPL, September 1998 (1998-09), page 39 XP000892394 ISSN: 0022-3573
  • FILION M C ET AL: "Mycobacterium phlei cell wall complex directly induces apoptosi in human bladder cancer cells" BRITISH JOURNAL OF CANCER,GB,LONDON, vol. 79, no. 2, January 1999 (1999-01), pages 229-235, XP002100762 ISSN: 0007-0920
  • READER S ET AL: "Mycobacterial cell wall-DNA complex (MCC) inhibits proliferation and induces apoptosis in androgen-dependent and independent human prostate cancer cells." BRITISH JOURNAL OF CANCER, vol. 80, no. SUPPL. 2, July 1999 (1999-07), page 76 XP000946798 Joint Meeting of the British Association for Cancer Research, the British Oncological Association, the Association of Cancer Physicians and the Royal College of Radiologists;Edinburgh, Scotland, UK; July 11-14, 1999 ISSN: 0007-0920
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).