(19)

(11)

EP 1 165 141 A2

(12)

(88) Date of publication A3: 18.01.2001 (43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00919496.0 (22) Date of filing: 21.03.2000

(51) International Patent Classification (IPC)7: A61K 47/44, A61P 3/06, A61K 31/19, A61K 31/216, A61K 31/22, A61K 9/48 (86) International application number: PCT/US0007/459 (87) International publication number: WO 0057/918 (05.10.2000 Gazette 2000/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.03.1999 US 283356 (71) Applicant: ABBOTT LABORATORIES Abbott Park, IL 60064-6050 (US)	(72) Inventors: LIU, Rong (Ron) Gurnee, IL 60031 (US) PAN, Qinghai Lake Bluff, IL 60044 (US) HANSRANI, Pawan Buffalo Grove, IL 60089 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)