(19)

(11)

EP 1 165 146 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00921373.7 (22) Date of filing: 09.03.2000

(51) International Patent Classification (IPC)7: A61K 51/00, C07F 5/00, A61N 5/00 (86) International application number: PCT/US0006/207 (87) International publication number: WO 0053/234 (14.09.2000 Gazette 2000/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.03.1999 US 123483 P (71) Applicant: Thomas Jefferson University Philadelphia, PA 19107-5587 (US)	(72) Inventor: THAKUR, Madhukar (Mathew) L. Cherry Hill, NJ 08003 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)