(19)

(11)

EP 1 165 147 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00925911.0 (22) Date of filing: 10.04.2000

(51) International Patent Classification (IPC)7: A61K 51/12, A61K 49/00 (86) International application number: PCT/US0009/477 (87) International publication number: WO 0061/197 (19.10.2000 Gazette 2000/42)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.04.1999 US 128516 P (71) Applicant: Phenome Sciences Inc. Woburn, MA 01801 (US)	(72) Inventor: AJAMI, Alfred, M. Brookline, MA 02445 (US) (74) Representative: Hofstetter, Alfons J., Dr.rer.nat. et al Hofstetter, Schurack & Skora Balanstrasse 57 81541 München 81541 München (DE)