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(11)

EP 1 165 513 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00916622.4 (22) Date of filing: 22.03.2000

(51) International Patent Classification (IPC)7: C07D 209/34, C07D 401/12, C07D 401/06, C07D 403/06, C07D 409/10, C07D 409/14, C07D 401/04, C07D 409/04, C07D 401/14, C07D 413/12, C07D 413/14, A61K 31/40 // (C07D401/12, 213:00), C07D209:00,(C07D401/06, 213:00), C07D209:00,(C07D409/10, 333:00), C07D209:00 (86) International application number: PCT/US0007/704 (87) International publication number: WO 0056/709 (28.09.2000 Gazette 2000/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.03.1999 US 125945 P 05.04.1999 US 127863 P 26.04.1999 US 131192 P 03.05.1999 US 132243 P (71) Applicant: Sugen, Inc. South San Francisco, CA 94080-4811 (US)

(72) Inventors: TANG, Peng, Cho Moraga, CA 94556 (US) SUN, Li Foster City, CA 94404 (US) MCMAHON, Gerald Kenwood, CA 95452 (US) MILLER, Todd, Anthony Union City, CA 94587 (US) SHIRAZIAN, Shahrzad Corte Madera, CA 94925 (US) WEI, Chung, Chen Foster City, CA 94404 (US) HARRIS, G., Davis San Francisco, CA 94114 (US) XIAOYUAN, Li San Jose, CA 95130 (US) LIANG, Congxin Sunnyvale, CA 94087 (US) (74) Representative: Viering, Jentschura & Partner  Steinsdorfstrasse 6 80538 München 80538 München (DE)