N-BENZIMIDAZOLYLMETHYL- AND N-INDOLYLMETHYL-BENZAMIDES AND THEIR USE AS CRF MODULATORS - Patent 1165517

(19)

(11)

EP 1 165 517 A1

(12)

(43)	Date of publication:
	02.01.2002 Bulletin 2002/01

(21)	Application number: 00918516.6

(22)	Date of filing: 31.03.2000

(51)	International Patent Classification (IPC)⁷: C07D 235/14, C07D 209/14, A61K 31/4184, A61K 31/4045, A61P 25/00, G01N 33/50

(86)	International application number:
	PCT/US0008/570

(87)	International publication number:
	WO 0059/888 (12.10.2000 Gazette 2000/41)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

(30)

Priority:

02.04.1999 US 127624 P
02.04.1999 US 285420

(71)	Applicant: NEUROGEN CORPORATION
	Branford, CT 06405 (US)

(72)	Inventors:
	HORVATH, Raymond, F. North Branford, CT 06471 (US) GE, Ping Branford, CT 06405 (US) YOON, Taeyoung East Haven, CT 06512 (US) HUTCHISON, Alan Madison, CT 06443 (US)

(74)	Representative: Smaggasgale, Gillian Helen et al
	W.P. Thompson & Co, Celcon House, 289-293 High Holborn London WC1V 7HU London WC1V 7HU (GB)

(54)	N-BENZIMIDAZOLYLMETHYL- AND N-INDOLYLMETHYL-BENZAMIDES AND THEIR USE AS CRF MODULATORS