BENZIMIDAZOLE AND IMIDAZOLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE MODULATORS OF BRADYKININ B2 (= BK-2) RECEPTORS - Patent 1165518

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EP 1 165 518 A2

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(88)	Date of publication A3:
	13.09.2001

(43)	Date of publication:
	02.01.2002 Bulletin 2002/01

(21)	Application number: 00919946.4

(22)	Date of filing: 31.03.2000

(51)	International Patent Classification (IPC)⁷: C07D 235/14, C07D 471/04, C07D 403/10, C07D 401/06, A61K 31/415, A61K 31/495, A61K 31/535, A61K 31/44 // (C07D471/04, 235:00), C07D221:00

(86)	International application number:
	PCT/US0008/568

(87)	International publication number:
	WO 0059/886 (12.10.2000 Gazette 2000/41)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

02.04.1999 US 127505 P
02.04.1999 US 285327

(71)	Applicant: NEUROGEN CORPORATION
	Branford, CT 06405 (US)

(72)	Inventors:
	DESIMONE, Robert, W. Durham, CT 06422 (US) HUTCHISON, Alan Madison, CT 06443 (US) SHAW, Kenneth Weston, CT 06883 (US) MAYNARD, George, D. Clinton, CT 06413 (US) PETERSON, John, M. Madison, CT 06443 (US) LEW, Richard Hamden, CT 06518 (US) BRIELMANN, Harry, L. Guilford, CT 06437 (US)

(74)	Representative: Smaggasgale, Gillian Helen
	W.P. Thompson & Co, Celcon House, 289-293 High Holborn London WC1V 7HU London WC1V 7HU (GB)

(54)	BENZIMIDAZOLE AND IMIDAZOLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE MODULATORS OF BRADYKININ B2 (= BK-2) RECEPTORS