(19)

(11)

EP 1 165 591 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00916590.3 (22) Date of filing: 22.03.2000

(51) International Patent Classification (IPC)7: C07H 21/04, C07K 14/00, C07K 16/00, C12N 15/00, C12N 15/63, C12N 15/85, C12N 15/86, C12Q 1/68, G01N 33/53 (86) International application number: PCT/US0007/534 (87) International publication number: WO 0058/335 (05.10.2000 Gazette 2000/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.03.1999 US 126598 P 22.12.1999 US 171504 P (71) Applicants: Human Genome Sciences, Inc. Rockville, MD 20850 (US) Rosen, Craig A. Laytonsville, MD 20882 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Laytonsville, MD 20882 (US) KOMATSOULIS, George Silver Spring, MD 20901 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)