(19)

(11)

EP 1 165 608 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00917976.3 (22) Date of filing: 15.03.2000

(51) International Patent Classification (IPC)7: C07K 14/47, C07K 14/705, G01N 33/53, G01N 33/567, C12N 5/10, C12N 15/12, C12N 15/63 (86) International application number: PCT/US0006/820 (87) International publication number: WO 0055/202 (21.09.2000 Gazette 2000/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.03.1999 US 125038 P 03.03.2000 US 519397 (71) Applicants: SmithKline Beecham Corporation Philadelphia, PA 19103 (US) Smithkline Beecham PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: JAMES, Ian, Edward Ardmore, PA 19003 (US) LARK, Michael, William Devon, PA 19333 (US) TESTA, Tania, Tamson London N21 3JT (GB) (74) Representative: Crump, Julian Richard John  FJ Cleveland, 40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)