(19)

(11)

EP 1 165 617 A2

(12)

(88) Date of publication A3: 21.12.2000 (43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00912183.1 (22) Date of filing: 03.03.2000

(51) International Patent Classification (IPC)7: C07K 16/20, C12N 5/20, A61K 39/395, A61P 33/06 (86) International application number: PCT/US0005/820 (87) International publication number: WO 0052/056 (08.09.2000 Gazette 2000/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.03.1999 US 122842 P 13.09.1999 US 153575 P (71) Applicant: EntreMed, Inc. Rockville, MD 20850 (US)	(72) Inventors: NARUM, David, L. Gaithersburg, MD 20879 (US) SIM, Kim, Lee Gaithersburg, MD 20878 (US) (74) Representative: Stevens, Ian Edward  Eric Potter Clarkson, Park View House, 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)