(19)

(11)

EP 1 165 752 A2

(12)

(88) Date of publication A3: 18.10.2001 (43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00975335.1 (22) Date of filing: 21.10.2000

(51) International Patent Classification (IPC)7: C12N 5/00, C12N 15/00, C12N 15/09, C12N 15/63, C07K 1/00, C07K 14/00, C07K 17/00 (86) International application number: PCT/US0029/151 (87) International publication number: WO 0130/966 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.10.1999 US 161186 P (71) Applicant: ALEXION PHARMACEUTICALS, INC. New Haven, CT 06511 (US)	(72) Inventors: FODOR, William, L. Madison, CT 06443 (US) PIZZOLATO, Maryellen Old Saybrook, CT 06475 (US) (74) Representative: Maschio, Antonio  D Young & Co, 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)