(19)

(11)

EP 1 165 774 A2

(12)

(88) Date of publication A3: 28.12.2000 (43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00912627.7 (22) Date of filing: 20.03.2000

(51) International Patent Classification (IPC)7: C12N 15/11, C12N 15/12, C07K 14/705, A61K 38/17, C12Q 1/68, G01N 33/68, C07K 16/30 (86) International application number: PCT/EP0002/478 (87) International publication number: WO 0058/460 (05.10.2000 Gazette 2000/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.03.1999 GB 9907113 25.09.1999 GB 9922858 (71) Applicant: SmithKline Beecham Biologicals s.a. 1330 Rixensart (BE)	(72) Inventors: BRUCK, Claudine, Elvire, Marie 1330 Rixensart (BE) CASSART, Jean-Pol 1330 Rixensart (BE) COCHE, Thierry 1330 Rixensart (BE) VINALS Y DE BASSOLS, Carlota 1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co., 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)