(19)

(11)

EP 1 165 776 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00910250.0 (22) Date of filing: 18.02.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, G01N 33/566, A61K 38/17, C07K 16/28, A61K 39/395, C12N 15/62 (86) International application number: PCT/US0004/326 (87) International publication number: WO 0050/589 (31.08.2000 Gazette 2000/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.02.1999 US 121170 P 08.10.1999 US 158566 P (71) Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH New York, New York 10158 (US)	(72) Inventors: CHIARI, Rita B-1200 Brussels (BE) COULIE, Pierre B-1200 Brussels (BE) BOON-FALLEUR, Thierry B-1200 Brussels (BE) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)