(19)
(11) EP 1 166 102 A1

(12)

(43) Date of publication:
02.01.2002 Bulletin 2002/01

(21) Application number: 00914803.2

(22) Date of filing: 03.03.2000
(51) International Patent Classification (IPC)7G01N 33/00, A01N 43/04, A61K 38/00, A61K 39/395, A61K 39/40, A61K 39/42, A61K 39/44, C07H 21/02, C07H 21/04, C12N 15/00, C12N 15/09, C12P 19/34
(86) International application number:
PCT/US0005/465
(87) International publication number:
WO 0052/462 (08.09.2000 Gazette 2000/36)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 03.03.1999 US 160083 P

(71) Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH
New York, New York 10158 (US)

(72) Inventors:
  • AASE, Karin,Ludwig Institute for Cancer Research
    S-171 77 Stockholm (SE)
  • THOREN, Peter,Karolinska Institute
    S-171 77 Stockholm (SE)
  • ERIKSSON, Ulf,Ludwig Institute Cancer Research
    S-171 77 Stockholm (SE)

(74) Representative: Harrison Goddard Foote 
Belgrave Hall Belgrave Street
Leeds LS2 8DD
Leeds LS2 8DD (GB)

   


(54) HEART ABNORMALITIES IN VASCULAR ENDOTHELIAL GROWTH FACTOR B (VEGF-B) DEFICIENT ANIMALS AND METHODS RELATING TO THESE HEART ABNORMALITIES