(19)

(11)

EP 1 166 111 A1

(12)

(43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 99916432.0 (22) Date of filing: 06.04.1999

(51) International Patent Classification (IPC)7: G01N 33/50, G01N 1/28 (86) International application number: PCT/US9907/573 (87) International publication number: WO 0060/353 (12.10.2000 Gazette 2000/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: GENZYME CORPORATION Framingham, MA 01701-9322 (US)	(72) Inventor: CHAN, Raymond Redwood City, CA 94065 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte, Possartstrasse 20 81679 München 81679 München (DE)