(19)

(11)

EP 1 166 117 A2

(12)

(88) Date of publication A3: 19.04.2001 (43) Date of publication: 02.01.2002 Bulletin 2002/01 (21) Application number: 00916513.5 (22) Date of filing: 17.03.2000

(51) International Patent Classification (IPC)7: G01N 33/569, C12Q 1/68, A61K 31/395, A61K 31/70, A61K 31/43, A61K 31/415, A61K 31/47, A61K 31/18, A61K 31/65 (86) International application number: PCT/US0007/226 (87) International publication number: WO 0057/187 (28.09.2000 Gazette 2000/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.03.1999 US 125598 P 18.01.2000 US 176662 P 18.01.2000 US 176940 P 18.01.2000 US 176784 P (71) Applicant: VANDERBILT UNIVERSITY Nashville, TN 37240 (US)

(72) Inventors: STRATTON, Charles, W. Nashville, TN 37215 (US) MITCHELL, William, M. Nashville, TN 37215 (US) YAO, Song-Yi Nashville, TN 37211 (US) BANNAN, Jason, D. Marassas, VA 20112 (US) LJUNGGREN-ROSE, Asa Clarksville, TN 37043 (US) SRIRAM, Subramaniam Nashville, TN 37215 (US) (74) Representative: Lock, Graham James et al Fry Heath & Spence, The Old College, 53 High Street Horley, Surrey RH6 7BN Horley, Surrey RH6 7BN (GB)