(19)

(11)

EP 1 169 048 A2

(12)

(88) Date of publication A3: 08.11.2001 (43) Date of publication: 09.01.2002 Bulletin 2002/02 (21) Application number: 99933718.1 (22) Date of filing: 06.07.1999

(51) International Patent Classification (IPC)7: A61K 38/02, C07K 2/00 (86) International application number: PCT/US9915/263 (87) International publication number: WO 0001/841 (13.01.2000 Gazette 2000/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.07.1998 US 91758 P 03.07.1999 US 347707 (71) Applicants: Prestwich, Glenn D. Salt Lake City, UT 84108 (US) Ziebell, Michael Salt Lake City, UT 84103 (US) Luo, Bai Salt Lake City, UT 84108 (US) Zhao, Zhan-gong Tucson, AZ 85718 (US)	(72) Inventors: Prestwich, Glenn D. Salt Lake City, UT 84108 (US) Ziebell, Michael Salt Lake City, UT 84103 (US) Luo, Bai Salt Lake City, UT 84108 (US) Zhao, Zhan-gong Tucson, AZ 85718 (US) (74) Representative: Leissler-Gerstl, Gabriele  Eisenführ, Speiser & Partner, Patentanwälte, Arnulfstrasse 25 80335 München 80335 München (DE)