(19)

(11)

EP 1 169 346 A1

(12)

(43) Date of publication: 09.01.2002 Bulletin 2002/02 (21) Application number: 00919418.4 (22) Date of filing: 16.03.2000

(51) International Patent Classification (IPC)7: C07K 14/47, C12N 5/10, C12N 5/16, C12N 15/12, C12N 15/19, C12N 15/63, C12N 15/64 (86) International application number: PCT/US0006/823 (87) International publication number: WO 0056/765 (28.09.2000 Gazette 2000/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.03.1999 US 125364 P 08.12.1999 US 169623 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Laytonsville, MD 20882 (US) KOMATSOULIS, George Silver Spring, MD 20901 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)