(19)

(11)

EP 1 169 440 A1

(12)

(43) Date of publication: 09.01.2002 Bulletin 2002/02 (21) Application number: 00917960.7 (22) Date of filing: 16.03.2000

(51) International Patent Classification (IPC)7: C12N 15/11, C12N 15/12, C12N 15/63, C12N 1/21, C12N 5/10, C07K 14/00, C07K 14/435, C07K 14/47 (86) International application number: PCT/US0006/782 (87) International publication number: WO 0056/881 (28.09.2000 Gazette 2000/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.03.1999 US 125812 P 10.12.1999 US 169936 P (71) Applicants: Human Genome Sciences, Inc. Rockville, MD 20850 (US) Rosen, Craig A. Laytonsville, MD 20882 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Laytonsville, MD 20882 (US) KOMATSOULIS, George Silver Spring, MD 20901 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)