(19)

(11)

EP 1 169 458 A2

(12)

(88) Date of publication A3: 10.05.2001 (43) Date of publication: 09.01.2002 Bulletin 2002/02 (21) Application number: 00921779.5 (22) Date of filing: 06.04.2000

(51) International Patent Classification (IPC)7: C12N 15/52, C12N 9/00, C12Q 1/25 (86) International application number: PCT/US0009/154 (87) International publication number: WO 0060/091 (12.10.2000 Gazette 2000/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.04.1999 US 127977 P (71) Applicant: Oklahoma Medical Research Foundation Oklahoma City Oklahoma 73104 (US)	(72) Inventors: SAUER, Brian, Lee Oklahoma City, OK 73102 (US) RUFER, Andreas, Walter Oklahoma City, OK 73103 (US) (74) Representative: Brasnett, Adrian Hugh  Mewburn Ellis York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)