(19)

(11)

EP 1 169 464 A1

(12)

(43) Date of publication: 09.01.2002 Bulletin 2002/02 (21) Application number: 00921951.0 (22) Date of filing: 07.04.2000

(51) International Patent Classification (IPC)7: C12N 15/861, C12N 7/01, A61K 48/00 (86) International application number: PCT/US0009/459 (87) International publication number: WO 0061/773 (19.10.2000 Gazette 2000/42)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.04.1999 US 289930 (71) Applicant: Schering-Plough Ltd. 6004 Lucerne (CH)	(72) Inventors: CHIANG, Christina, H. San Diego, CA 92130 (US) COCHRAN, Mark, D. Carlsbad, CA 92008 (US) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)