(19)
(11) EP 1 171 109 A1

(12)

(43) Date of publication:
16.01.2002 Bulletin 2002/03

(21) Application number: 00923415.4

(22) Date of filing: 14.04.2000
(51) International Patent Classification (IPC)7: A61K 31/155, A61K 39/395, A61P 37/02
// A61K39:395, A61K31:155
(86) International application number:
PCT/US0010/253
(87) International publication number:
WO 0061/132 (19.10.2000 Gazette 2000/42)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 14.04.1999 US 291712

(71) Applicants:
  • THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Rockville, MD 20852-3804 (US)
  • THE UAB RESEARCH FOUNDATION
    Birmingham, AL 35294-0111 (US)

(72) Inventors:
  • NEVILLE, David, M.
    Bethesda, MD 20814 (US)
  • THOMAS, Judith, M.
    Birmingham, AL 35242 (US)

(74) Representative: Leissler-Gerstl, Gabriele 
Eisenführ, Speiser & Partner, Patentanwälte, Arnulfstrasse 25
80335 München
80335 München (DE)

   


(54) COMPOSITIONS CONTAINING IMMUNOTOXINS AND AGENTS THAT INHIBIT DENDRITIC CELL MATURATION FOR INDUCING IMMUNE TOLERANCE TO A GRAFT