(19)

(11)

EP 1 173 415 A1

(12)

(43) Date of publication: 23.01.2002 Bulletin 2002/04 (21) Application number: 00920908.1 (22) Date of filing: 19.04.2000

(51) International Patent Classification (IPC)7: C07C 275/40, C07D 295/15, C07D 209/02, A61K 31/17, A61K 31/445, A61K 31/496, A61K 31/5375 (86) International application number: PCT/GB0001/542 (87) International publication number: WO 0064/866 (02.11.2000 Gazette 2000/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.04.1999 GB 9909409 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventor: OLDHAM, Keith Cheshire SK10 4TG (GB) (74) Representative: Bill, Kevin et al AstraZeneca, Global Intellectual Property, Patents, P.O. Box 272, Mereside, Alderley Park Macclesfield, Cheshire SK10 4GR Macclesfield, Cheshire SK10 4GR (GB)